pSivida Corp


Diabetic Macular Edema (DME) is one of the largest causes of vision loss in the developed world and is one of several diabetic eye diseases. Diabetic eye disease refers to a group of eye problems that people with diabetes may face as a complication of diabetes. All can cause severe vision loss or even blindness.

Diabetic eye disease may include:

In some people with diabetic retinopathy, blood vessels may swell and leak fluid. In other people, abnormal new blood vessels grow on the surface of the retina. The retina is the light-sensitive tissue at the back of the eye. A healthy retina is necessary for good vision. When fluid leaks into the center of the macula, the part of the eye where sharp, straight-ahead vision occurs, the fluid makes the macula swell, blurring vision. This condition is called macular edema. It can occur at any stage of diabetic retinopathy, although it is more likely to occur as the disease progresses.

ILUVIEN, the Company's most recent approved product, is licensed to Alimera Sciences, Inc (Alimera). ILUVIEN in an injectable, non-erodible, intravitreal implant for the treatment of diabetic macular edema (DME) and releases the drug fluocinolone acetonide (FA) for periods up to 36 months. ILUVIEN has FDA approval in the US and received marketing authorization for chronic DME considered insufficiently responsive to available therapies in 17 EU countries.

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